Microsoft has released a PDF Document showing users what to do to tune Vista for a better performance. The Guide that is available for download here can be categorized as a good start point and I hope that Microsoft keep posting other guides like this one.
Vista Performance and Tuning Guide. It is available as a download through the Microsoft site and will guide you through the most common changes you can make to Vista to get better performance, especially out of computers with borderline components such as mobile PCs. Give it a try and see how it works for your setup.